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License: Licence of this font is freeware, for commercial purposes (such as publication, web design, printing etc.) you need to buy original licence.Fibrinogen: an update on its role in the coagulation cascade. Human fibrinogen is a 340 kDa glycoprotein composed of three pairs of nonidentical polypeptide chains, which become covalently linked together by a process of enzymatic polymerization to form an insoluble fibrin clot. This molecule is synthesized in the liver and in the megakaryocytes, which are located in the bone marrow. Studies on fibrinogen synthesis in the liver have shown that the α, β, and γ polypeptide chains are independently regulated; the regulation is however not complete and the synthesis of only one of the three chains is affected by changes in the nutritional status of the patient. The γ-chain synthesis is controlled by an independent regulatory pathway which is subjected to a positive (growth factors and cytokines) and a negative feedback (APC-C3 convertase). The other two chains are regulated by the APC-C3 convertase, which is responsible for the inhibitory feedback on the synthesis of the β-chain. The interaction of these three chains with each other is also regulated, but only the γ chain forms a high-molecular-weight complex with the α and β chains, the latter two chains remaining linked to form a low-molecular-weight complex. The formation of the fibrin clot is regulated by a series of enzymes and it is not until the final moment of the coagulation cascade that fibrin is formed. Fibrinogen is degraded by the plasmin/plasminogen system. In this review the role of fibrinogen in the coagulation cascade is discussed.6-year-old Girl Killed in Western Mass. A 6-year-old New York girl has died after being hit by a car in western Massachusetts. The Berkshire Eagle reports that officials say the girl was walking in a crosswalk with her mother Monday when she was struck by a pickup truck that didn’t stop. 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